Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers
Figure 5
ALDHbr tumor cells exhibit cancer stem cell properties.
A. ALDHbr cell populations (Blue) generated significantly higher numbers of mammospheres compared to the ALDHlow population (Yellow). B. Tumorigenicity of the ALDHbr and ALDHlow cells were examined in vitro using colony formation assays. C. Tumorigenicity of the ALDHbr and ALDHlow cells were examined in vivo. D. Histology of the ALDHbr and ALDHlow BT-474 tumors was examined by HE staining. E. Proliferation of the ALDHbr and ALDHlow BT-474 tumors was examined by Ki-67 immunostaining.