Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis
Figure 5
Mps1 inhibition accelerates mitosis.
A–C: Time-lapse analysis by DIC microscopy of mitotic progression of HCT-derived (A, B) and UTR-derived (C) cells treated with DMSO or 23dMB-PP1. Images in A display morphology of HCT-derived cells imaged at the indicated timepoints after NEB (nuclear envelope breakdown). Graphs in B and C show cumulative percentages of cells that display first signs of furrowing at indicated times after NEB. Dashed lines indicate half-time to furrowing.