Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II
Figure 5
Cytotoxicity correlates with the ability of voreloxin and analogs to intercalate DNA.
A549 cells were treated for 72 h with a dose-titration (0.0001–10 µM) of voreloxin or analog, each treatment point performed in triplicate, N = 2, and the inhibition of proliferation analyzed by MTT assay. Error bars represent standard error of the mean (SEM) for the two independent experiments. The potency of the analogs relative to voreloxin was compared using IC50 values. The compound structures are inset, with the fused phenyl and phenyl rings highlighted by arrow or box, respectively.