Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II
Figure 1
Voreloxin is a quinolone derivative.
The chemical structures of voreloxin, ciprofloxacin and doxorubicin are shown. The core naphthyridine, quinolone, and anthracycline components are circled. Similarities between the core of the naphthyridine and quinolone are evident, as is the chemical dissimilarity between these two classes of compounds and the anthracyclines.