A Comparison of Azacitidine and Decitabine Activities in Acute Myeloid Leukemia Cell Lines
Figure 5
AZA and DAC reduce DNA methylation in KG-1a and THP-1 cells.
Cells were treated daily with AZA (•) or DAC (□) (0–3 µM) for 48 hours. DNA methylation was measured using (A) pyrosequencing of LINE-1 DNA elements in bisulfite-converted DNA and (B) Illumina GoldenGate platform. AZA = azacitidine; DAC = decitabine.