A Role for BK Channels in Heart Rate Regulation in Rodents
Figure 1
The effects of lolitrem B and paxilline on blood pressure and heart rate in Kcnma1−/− mice and wild-type littermates.
Inhibitors were added immediately after the control reading at time zero as indicated by the arrow. Mean blood pressure following treatment with (A) 4 mg/kg lolitrem B, or (B) 8 mg/kg paxilline. Heart rate following treatment with (C) lolitrem B, or (D) paxilline. Data are mean ± S.E.M. for n = 4 in each treatment group. Significance was tested using Tukey-Kramer post hoc test after a repeated measures analysis of variance. Asterisks indicate the significance of each treatment in wild-type mice compared with the pre-drug control at time = 0. *, P<0.05; **, P<0.01; ***, P<0.001.