Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
Figure 7
Alignment of β-secretase substrates and putative cleavage sites.
The primary amino acid sequence of BACE1 substrates (A) and non-substrates (B) are shown. The first ten amino acids of the transmembrane domain are included, if present. Known cleavage sites are indicated with a black box and arrowhead, and potential cleavage sites are in gray. All sequences are human, except ST6Gal I, whose cleavage site was determined in rat. Sequence from type II proteins is listed from C- to N-terminal to maintain membrane orientation.