Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
Figure 6
Single pass membrane proteins unaltered by β-secretase activity.
Endogenous membrane proteins nicastrin (Nct, A) and Itgβ1 (B) were found not to be shed by BACE1 or another secretase. ACE (C) and BACE1 (D) were both shed by metalloproteases, but not affected by β-secretase activity. Left panels are from cell lysates, and right panels are from conditioned medium.