The Contribution of TRPM8 and TRPA1 Channels to Cold Allodynia and Neuropathic Pain
Figure 5
Proportions of cold, (-)-menthol and mustard oil responsive DRG neurons in control animals, at 7 and 14 days post-CCI and at 48 hours post CFA.
(a), Cell-size histogram in control mice and in mice at 7 and 14 days post CCI injury. (b), Percentage of cold-responsive neurons in the DRG (n = 6–15 mice). (c), Percentage of neurons responsive to 100 µM menthol (n = 6–15 mice). (d), Concentration-response profile for menthol. (e), Percentage of mustard oil-responsive neurons (n = 3 mice in each group). (f), Percentage of neurons responding to mustard oil in DRG ipsilateral and contralateral to CFA injection (n = 3 mice). (g), Maximum amplitude of Ca2+ transients in mustard oil sensitive neurons following CFA injection. (h), Percentage of neurons in the DRG responsive to both (-)-menthol and cold (n = 6–11). (i), Percentage of neurons in the DRG insensitive to (-)-menthol but responsive to cold (n = 6–11). I indicates ipsilateral to the injury, C contralateral. *P<0.05 ipsilateral versus contralateral, paired T-test. All values are mean±SEM.