Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo
Figure 6
Effect of A1 adenosine receptor (AR) antagonist DPCPX in AR gene targeted mice.
Following insertion of a catheter into the common carotid artery, mean arterial blood pressure and heart rate were measured after injection of vehicle or adenosine at indicated doses (volume of 100 µl). All animals received 1 mg/kg of the A1AR antagonist DPCPX (i.p., 30 min prior to the experimental procedure) or vehicle. Relative changes in HR and MAP are displayed. (A, B) A1AAR−/− (C, D) A2AAR−/− (E, F) A2BAR−/− (n = 4;* p<0.05 compared to DPCPX treated mice; #p<0.05 compared to adenosine-vehicle; mean±SEM).