Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo
Figure 5
Effect of A1AR antagonist DPCPX on adenosine-induced slowing of the heart-rate.
Following insertion of a catheter into the common carotid artery, mean arterial blood pressure and heart rate were measured after injection of vehicle or adenosine at indicated doses (volume of 100 µl). All animals received 1 mg/kg of the A1AR antagonist DPCPX (i.p., 30 min prior to the experimental procedure) or vehicle. (A, B) Heart-rate or mean arterial blood pressure at indicated time points. (C, D) Relative changes of heart-rate or mean arterial blood pressure (n = 4, * indicates p<0.05 compared to DPCPX treatment; #indicates p<0.05 compared to adenosine-vehicle injection; mean±SEM).