Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo
Figure 4
Effect of systemic adenosine administration in AR gene targeted mice.
Following insertion of a catheter into the common carotid artery, mean arterial blood pressure and heart rate were measured. A2AAR−/−, A2BAR−/− orA3AR−/− received bolus injections of vehicle solution or indicated doses of adenosine in 100 µl of vehicle. Change in heart-rate and mean arterial pressure compared to littermate control mice. (A, B) A2AAR−/− (C, D) A2BAR−/− (E, F) A3AR−/− (n = 6–8, *p<0.05 compared to adenosine-vehicle; mean±SEM).