Selective Deletion of the A1 Adenosine Receptor Abolishes Heart-Rate Slowing Effects of Intravascular Adenosine In Vivo
Figure 3
Adenosine bolus injections in gene-targeted mice for the A1AR.
Following insertion of a catheter into the common carotid artery, mean arterial blood pressure and heart rate were measured A1AR−/−-mice received bolus injection of vehicle or indicated doses of adenosine (100 µl) via the carotid artery catheter. (A, B) Heart-rate and blood pressure responses to 100 µg of adenosine compared to wild type mice. (C, D) Relative changes in heart-rate and mean arterial blood pressure. Note: A1AR−/−-mice experience no change in HR following bolus injection of adenosine. (n = 7–8; WT n = 8, *p<0.05 A1AR−/− vs WT; #p<0.05 compared to adenosine-vehicle; mean±SEM;).