Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection
Figure 9
Effects of prostratin+SAHA treatment on HIV-1 recovery in HLA DR− CD4+ T cells.
HLA DR− CD4+ T cells from HAART-treated patients with undetectable viral load (X43 to X51) were mock-treated or treated with the combination prostratin (5 µM)+SAHA (2.5 µM). Six days after treatment, HIV-1 genomic RNA concentrations were measured in culture supernatants as described in Materials and Methods.