3D Model of Lamprey Estrogen Receptor with Estradiol and 15α-Hydroxy-Estradiol
Figure 5
Interaction of 15α-OH-E2 with human ERα and the 3D model lamprey ER.
A. In human ERα, Cγ2 on Ile-424 and Cε on Met-421 have van der Waals contacts with 15α-OH-E2. B. Lamprey ER has stabilizing interactions with the A ring of 15α-OH-E2 that are similar to those in human ERα. His-509 has rotated and does not form a hydrogen bond with the C17-hydroxyl on E2. Cδ2 on His-509 has a van der Waals contact with the C17-hydroxyl. Sδ on Met-406 and Met-409 stabilize 15α-OH-E2.