3D Model of Lamprey Estrogen Receptor with Estradiol and 15α-Hydroxy-Estradiol
Figure 4
Interaction of E2 with human ERα and the 3D model lamprey ER.
A. Interaction between E2 and human ERα. B. Interaction between E2 and the 3D model of lamprey ER. Lamprey ER has stabilizing interactions with the A ring of E2 similar to those in human ERα. His-509 has rotated and does not have a hydrogen bond with the C17-hydroxyl on E2. Instead, Cδ2 has a van der Waals contact with the C17-hydroxyl on E2. Also, Cε and Sδ on Met-409 have stabilizing contacts with C15 on E2.