3D Model of Lamprey Estrogen Receptor with Estradiol and 15α-Hydroxy-Estradiol
Figure 2
Alignment of lamprey ER with human ERα and human ERβ.
α-helices and β-strands from the crystal structures of ERα and ERβ are shaded in each sequence and notated below the alignment. Residues in human ERα involved in binding of estradiol are shown in green. Glu-419, which stabilizes His-524 is shaded in brown. Crystal structure accessions are human ERα [PDB: 1G50], human ERβ [1QKM].