Unusual Armadillo Fold in the Human General Vesicular Transport Factor p115
Figure 2
(A) Stereo view of the overall structure. The protein is composed of 11 armadillo repeats. (B) Structure-based sequence alignment of the p115 armadillo repeats and the loop regions. Consensus residues that define the conserved hydrophobic residues of each armadillo repeat are highlighted in blue; amino acids that define conserved polar, neutral residues are highlighted in green. Glycine and proline residues are highlighted in brown and olive, respectively. The repeat numbers are shown on the left. The sequences that form helices H1, H2, and H3 are indicated as green, blue and yellow cylinders. The corresponding ARM loops are marked on top, the USO helix is indicated as red cylinder. (C) N-terminal armadillo-like helical domain (left) and C-terminal Uso1 head domain (right) of p115GHR, elongated loops with at least 5 residues are colored in red (H1 green, H2 blue, H3 yellow).