Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease
Figure 1
Sequencing of TCF-4 (TCF7L2) 5′upstream putative promoter region.
Sequencing of a 2.1 kb upstream region was performed in 10 healthy controls and 10 patients with ileal Crohn's disease. Putative regulatory regions were determined using promoter prediction software. Likely and marginal prediction sites are depicted as red boxes (upper panel). Relative location of identified variants is marked via grey dashes (upper part) and their allele frequency is demonstrated via bars for controls as well as patients (lower part).