Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)
Figure 5
(A) Schematic representation of the object recognition test. Mice are allowed to explore an identical pair of objects, and after 24 hours, they are presented with the familiar object and a new object. (B) Dyrk1A+/− exhibited significantly impaired novel object recognition as shown by the similar amount of time spent in exploring the two objects (familiar and new). (C) Dyrk1A+/− showed no net preference between novel and familiar objects as shown by the reduced discrimination index. White bars (Dyrk1A+/+) and black bars (Dyrk1A+/−) represent means±SEM.