Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)
Figure 2
Non-searching strategies in the Morris water maze test.
Floating behavior (A and B) was operationally defined as any period equal to or longer than 5 s, during which the average mouse swimming speed stayed below 3 cm.s−1. (A) Number of floating episodes; (B) Cumulative floating time (s); (C) Time in center-periphery during acquisition sessions. Dyrk1A+/− (black bars) mice spent more time in peripheral zone than control mice (white bars) during acquisition sessions. Dotted curves show the decrease of time in the peripheral zone between the first and fourth acquisition session. (D) Time (%) in center-periphery calculated for the cued, removal and reversal sessions. Data are shown as mean±SEM. ** P<0,005, Student's t test. Abbreviations: REM, removal session; REV, reversal session; C, center; P, periphery.