Ticagrelor and gut microbiota: Absence of pharmacokinetic interaction in vitro and in vivo studies

• Pan Qu ,

  Contributed equally to this work with: Pan Qu, Yongchao Gao

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China, Department of Pharmacy, Hunan Prevention and Treatment Institute for Occupational Diseases, Affiliated Prevention and Treatment Institute for Occupational Diseases of University of South China, Changsha, China

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• Yongchao Gao ,

  Contributed equally to this work with: Pan Qu, Yongchao Gao

  Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

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• Xiaojie Li,

  Roles Investigation, Writing – review & editing

  Affiliation The First Affiliated Hospital of Shantou University Medical College, Shantou, China

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• Li Yang,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Pharmacy, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, China

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• Jie Tang,

  Roles Methodology, Writing – original draft

  Affiliation Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

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• Manyun Chen,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

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• Yicheng Wang,

  Roles Methodology, Visualization, Writing – review & editing

  Affiliation Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

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• Yilei Peng,

  Roles Methodology, Writing – review & editing

  Affiliation Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

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• Junyi Jiang,

  Roles Data curation, Writing – review & editing

  Affiliation Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

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• Weihua Huang,

  Roles Writing – review & editing

  Affiliation Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

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• Wei Zhang,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

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• Yali Liu ,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

  * E-mail: 418500246@qq.com (YO); lydialyl@126.com (YL)

  Affiliation The First Affiliated Hospital of Shantou University Medical College, Shantou, China

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• Yali Ou

  Roles Funding acquisition, Investigation, Methodology, Writing – review & editing

  * E-mail: 418500246@qq.com (YO); lydialyl@126.com (YL)

  Affiliations Engineering Research Center of Applied Technology of Pharmacogenomics (Ministry of Education, China), Hunan Key Laboratory of Pharmacomicrobiomics, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China, Department of Cardiovascular, Xiangya Hospital, Central South University, Changsha, China

  https://orcid.org/0000-0001-5201-4090

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