From preclinical promise to regulatory reality: translation of small rodent acute injury therapies to human approval and safety outcomes: A systematic review

• Timothy R. Entwistle,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Pebble Institute, Manchester, United Kingdom, Pebble Biotechnology Laboratories, Manchester, United Kingdom

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• William R. Cowey,

  Roles Data curation, Formal analysis, Methodology, Project administration, Writing – review & editing

  Affiliations Pebble Institute, Manchester, United Kingdom, Pebble Biotechnology Laboratories, Manchester, United Kingdom

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• Eliza Stokoe,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Pebble Institute, Manchester, United Kingdom

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• John P. Stone,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Pebble Institute, Manchester, United Kingdom, Pebble Biotechnology Laboratories, Manchester, United Kingdom

  https://orcid.org/0000-0001-9452-2843

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• James E. Fildes

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: james.fildes@pebble.bio

  Affiliations Pebble Institute, Manchester, United Kingdom, Pebble Biotechnology Laboratories, Manchester, United Kingdom

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