L-(+)-Ergothioneine ameliorates preeclampsia-associated vascular endothelial dysfunction by modulating the Nrf2-PPARγ-sFlt-1 axis

Jingjin Gong; Yan Liu; Qingju Meng; Junwei Wu; Fang Chen; Yanwen Xu; Yanqiu Li; Qiwei Luo

doi:10.1371/journal.pone.0358574

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Open Access

Peer-reviewed

Research Article

L-(+)-Ergothioneine ameliorates preeclampsia-associated vascular endothelial dysfunction by modulating the Nrf2-PPARγ-sFlt-1 axis

Jingjin Gong ,

Contributed equally to this work with: Jingjin Gong, Yan Liu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft

Affiliation Obstetrics Department, Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital/Panyu Women and Children’s Medical Center, Guangdong Medical University (Guangzhou Panyu District Maternal and Child Health Hospital), Guangzhou, Guangdong, China
⨯
Yan Liu ,

Contributed equally to this work with: Jingjin Gong, Yan Liu

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangdong Medical University, Zhanjiang, Guangdong, China

https://orcid.org/0000-0003-2649-2552

⨯
Qingju Meng,

Roles Investigation, Methodology, Project administration

Affiliation Obstetrics Department, Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital/Panyu Women and Children’s Medical Center, Guangdong Medical University (Guangzhou Panyu District Maternal and Child Health Hospital), Guangzhou, Guangdong, China
⨯
Junwei Wu,

Roles Project administration, Resources, Software, Supervision

Affiliation Obstetrics Department, Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital/Panyu Women and Children’s Medical Center, Guangdong Medical University (Guangzhou Panyu District Maternal and Child Health Hospital), Guangzhou, Guangdong, China
⨯
Fang Chen,

Roles Funding acquisition, Supervision, Validation, Visualization, Writing – original draft

Affiliation Obstetrics Department, Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital/Panyu Women and Children’s Medical Center, Guangdong Medical University (Guangzhou Panyu District Maternal and Child Health Hospital), Guangzhou, Guangdong, China
⨯
Yanwen Xu,

Roles Supervision, Validation, Visualization, Writing – original draft

Affiliation Obstetrics Department, Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital/Panyu Women and Children’s Medical Center, Guangdong Medical University (Guangzhou Panyu District Maternal and Child Health Hospital), Guangzhou, Guangdong, China
⨯
Yanqiu Li ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft

* E-mail: liyanqiu1977@163.com (YL); 3251627824@qq.com (QL)

Affiliation Obstetrics Department, Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital/Panyu Women and Children’s Medical Center, Guangdong Medical University (Guangzhou Panyu District Maternal and Child Health Hospital), Guangzhou, Guangdong, China
⨯
Qiwei Luo

Roles Supervision, Validation, Visualization, Writing – review & editing

* E-mail: liyanqiu1977@163.com (YL); 3251627824@qq.com (QL)

Affiliation Obstetrics Department, Affiliated Hospital Group of Guangdong Medical University Panyu He Xian Memorial Hospital/Panyu Women and Children’s Medical Center, Guangdong Medical University (Guangzhou Panyu District Maternal and Child Health Hospital), Guangzhou, Guangdong, China
⨯

L-(+)-Ergothioneine ameliorates preeclampsia-associated vascular endothelial dysfunction by modulating the Nrf2-PPARγ-sFlt-1 axis

Jingjin Gong,
Yan Liu,
Qingju Meng,
Junwei Wu,
Fang Chen,
Yanwen Xu,
Yanqiu Li,
Qiwei Luo

Published: September 18, 2026
https://doi.org/10.1371/journal.pone.0358574

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