Reprogramming M2 macrophages via TLR7/8 agonist-loaded hollow MnO2 nanovehicles to suppress the progression of liver cancer

Pei-pei He; Zheng-ju Hou; Han-mei Li; Ji-xuan Zhang; An-Qi Chen; Quan-you Miao; Chao-Feng Yang; Jin-hong Yu; Yang Li

doi:10.1371/journal.pone.0358567

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Open Access

Peer-reviewed

Research Article

Reprogramming M2 macrophages via TLR7/8 agonist-loaded hollow MnO₂ nanovehicles to suppress the progression of liver cancer

Pei-pei He ,

Contributed equally to this work with: Pei-pei He, Zheng-ju Hou

Roles Conceptualization, Writing – original draft

Affiliations Department of Radiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Innovation Centre for Science and Technology of North Sichuan Medical College, Nanchong, Sichuan, China, Biotechnology Innovation Drug Application and Transformation Key Laboratory of Sichuan Province, North Sichuan Medical College, Nanchong, Sichuan Province, China

https://orcid.org/0009-0005-8899-2722

⨯
Zheng-ju Hou ,

Contributed equally to this work with: Pei-pei He, Zheng-ju Hou

Roles Conceptualization, Writing – original draft

Affiliations Department of Radiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Innovation Centre for Science and Technology of North Sichuan Medical College, Nanchong, Sichuan, China, Biotechnology Innovation Drug Application and Transformation Key Laboratory of Sichuan Province, North Sichuan Medical College, Nanchong, Sichuan Province, China
⨯
Han-mei Li,

Roles Visualization

Affiliations Innovation Centre for Science and Technology of North Sichuan Medical College, Nanchong, Sichuan, China, Department of Ultrasound, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Ji-xuan Zhang,

Roles Data curation, Formal analysis, Validation

Affiliations Department of Radiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Innovation Centre for Science and Technology of North Sichuan Medical College, Nanchong, Sichuan, China
⨯
An-Qi Chen,

Roles Data curation, Formal analysis, Validation

Affiliations Department of Radiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, Innovation Centre for Science and Technology of North Sichuan Medical College, Nanchong, Sichuan, China, Biotechnology Innovation Drug Application and Transformation Key Laboratory of Sichuan Province, North Sichuan Medical College, Nanchong, Sichuan Province, China
⨯
Quan-you Miao,

Roles Data curation, Formal analysis, Validation

Affiliation Department of Radiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Chao-Feng Yang,

Roles Data curation, Formal analysis, Validation

Affiliation Department of Radiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Jin-hong Yu ,

Roles Writing – review & editing

* E-mail: liyang811111@163.com (YL); yujinhong@nsmc.edu.cn (JY)

Affiliation Department of Ultrasound, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
⨯
Yang Li

Roles Writing – review & editing

* E-mail: liyang811111@163.com (YL); yujinhong@nsmc.edu.cn (JY)

Affiliation Department of Radiology, Afﬁliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
⨯

Reprogramming M2 macrophages via TLR7/8 agonist-loaded hollow MnO₂ nanovehicles to suppress the progression of liver cancer

Pei-pei He,
Zheng-ju Hou,
Han-mei Li,
Ji-xuan Zhang,
An-Qi Chen,
Quan-you Miao,
Chao-Feng Yang,
Jin-hong Yu,
Yang Li

Published: September 18, 2026
https://doi.org/10.1371/journal.pone.0358567

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