Associations between serum lactate and renal dysfunction in diabetic kidney disease: An exploratory analysis integrating animal experiments, clinical cohorts, and bioinformatic approaches

Zongtao Li; Wenyu Zhang; Die Fang; Bingwu Zhao; Tianwei Zhang; Xueqin Zhang; Zhiqiang Chen

doi:10.1371/journal.pone.0358359

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Open Access

Peer-reviewed

Research Article

Associations between serum lactate and renal dysfunction in diabetic kidney disease: An exploratory analysis integrating animal experiments, clinical cohorts, and bioinformatic approaches

Zongtao Li ,

Contributed equally to this work with: Zongtao Li, Wenyu Zhang

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft

Affiliation Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China
⨯
Wenyu Zhang ,

Contributed equally to this work with: Zongtao Li, Wenyu Zhang

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft

Affiliation Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China
⨯
Die Fang,

Roles Data curation, Investigation, Methodology, Validation

Affiliation Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China
⨯
Bingwu Zhao,

Roles Data curation, Investigation, Validation

Affiliation Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China
⨯
Tianwei Zhang,

Roles Data curation, Investigation, Validation

Affiliation Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China
⨯
Xueqin Zhang ,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft

* E-mail: zhangxueqin@hebcm.edu.cn (XZ); chenzhqiang2011@163.com (ZC)

Affiliation Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China
⨯
Zhiqiang Chen

Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

* E-mail: zhangxueqin@hebcm.edu.cn (XZ); chenzhqiang2011@163.com (ZC)

Affiliations Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China, First Affiliated Hospital of Hebei University of Traditional Chinese Medicine, Shijiazhuang, Hebei, China

https://orcid.org/0000-0001-6590-739X

⨯

Associations between serum lactate and renal dysfunction in diabetic kidney disease: An exploratory analysis integrating animal experiments, clinical cohorts, and bioinformatic approaches

Zongtao Li,
Wenyu Zhang,
Die Fang,
Bingwu Zhao,
Tianwei Zhang,
Xueqin Zhang,
Zhiqiang Chen

Published: September 15, 2026
https://doi.org/10.1371/journal.pone.0358359

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Protein interaction networks
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Creatinine
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