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Open Access

Peer-reviewed

Research Article

Isoquercitrin ameliorates chondrocyte dysfunction in osteoarthritis by targeting AKT1-mediated mitochondrial dynamics regulation

Yuan Ding,

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Department of Rheumatology and Immunology, Yantaishan Hospital, Yantai, Shandong Province, China
⨯
Xiang Wang,

Roles Methodology, Validation

Affiliation Department of Nephrology, Yantaishan Hospital, Yantai, Shandong Province, China
⨯
Shihua Zong,

Roles Investigation, Project administration

Affiliation Department of Rheumatology and Immunology, Yantaishan Hospital, Yantai, Shandong Province, China
⨯
Qiong Wen,

Roles Visualization, Writing – original draft

Affiliation Department of Rheumatology and Immunology, Yantaishan Hospital, Yantai, Shandong Province, China
⨯
Luyang Zhang

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: Zhangluyang8@126.com

Affiliation Department of Rheumatology and Immunology, Yantaishan Hospital, Yantai, Shandong Province, China

https://orcid.org/0009-0006-3472-5271

⨯

Isoquercitrin ameliorates chondrocyte dysfunction in osteoarthritis by targeting AKT1-mediated mitochondrial dynamics regulation

Yuan Ding,
Xiang Wang,
Shihua Zong,
Qiong Wen,
Luyang Zhang

x

Published: September 17, 2026
https://doi.org/10.1371/journal.pone.0357989

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Mitochondria
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Chondrocytes
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Analysis of variance
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Osteoarthritis
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Cytokines
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Inflammation
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Quantitative analysis
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Protein expression
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