Environmental PFOA exposure and the risk of metabolic dysfunction-associated steatotic liver disease: An integrated computational toxicology and multi-omics study

Tianyu Zhang; Yu Yuan; Chunli Lin; Chao Song; Tianrong Liao; Yuewen Sun; Hongzhen Tang

doi:10.1371/journal.pone.0357970

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Open Access

Peer-reviewed

Research Article

Environmental PFOA exposure and the risk of metabolic dysfunction-associated steatotic liver disease: An integrated computational toxicology and multi-omics study

Tianyu Zhang ,

Contributed equally to this work with: Tianyu Zhang, Yu Yuan

Roles Conceptualization, Data curation, Software, Writing – original draft

Affiliation Department of Acupuncture and Tuina, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Yu Yuan ,

Contributed equally to this work with: Tianyu Zhang, Yu Yuan

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Acupuncture and Tuina, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Chunli Lin,

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Acupuncture and Tuina, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Chao Song,

Roles Investigation, Validation, Writing – original draft

Affiliation Department of Acupuncture and Tuina, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Tianrong Liao,

Roles Formal analysis, Investigation, Validation, Writing – original draft

Affiliation Department of Acupuncture and Tuina, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Yuewen Sun,

Roles Data curation, Investigation, Validation, Writing – review & editing

Affiliation Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China
⨯
Hongzhen Tang

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: thz201807@126.com

Affiliation Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China

https://orcid.org/0009-0004-7419-8483

⨯

Environmental PFOA exposure and the risk of metabolic dysfunction-associated steatotic liver disease: An integrated computational toxicology and multi-omics study

Tianyu Zhang,
Yu Yuan,
Chunli Lin,
Chao Song,
Tianrong Liao,
Yuewen Sun,
Hongzhen Tang

Published: September 9, 2026
https://doi.org/10.1371/journal.pone.0357970

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