Ketogenic diet–induced changes in hepatic drug metabolism with potential implications for ozanimod pharmacokinetics in mice

Veronika Frybortova; Stefan Satka; Lenka Jourova; Pavel Anzenbacher; Iveta Zapletalova; Michal Kraus; Klara Kostovcikova; Miloslav Kverka; Eva Anzenbacherova

doi:10.1371/journal.pone.0357797

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Open Access

Peer-reviewed

Research Article

Ketogenic diet–induced changes in hepatic drug metabolism with potential implications for ozanimod pharmacokinetics in mice

Veronika Frybortova,

Roles Investigation, Methodology, Writing – original draft

Affiliation Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

https://orcid.org/0000-0002-9115-7091

⨯
Stefan Satka,

Roles Investigation

Affiliation Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

https://orcid.org/0000-0001-9485-2308

⨯
Lenka Jourova ,

Roles Conceptualization, Writing – review & editing

* E-mail: lenka.jourova@upol.cz

Affiliation Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

https://orcid.org/0000-0003-3195-6710

⨯
Pavel Anzenbacher,

Roles Supervision, Writing – review & editing

Affiliation Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic
⨯
Iveta Zapletalova,

Roles Investigation

Affiliation Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

https://orcid.org/0000-0003-0869-8848

⨯
Michal Kraus,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
⨯
Klara Kostovcikova,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic
⨯
Miloslav Kverka,

Roles Supervision, Writing – review & editing

Affiliation Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic

https://orcid.org/0000-0002-1335-5252

⨯
Eva Anzenbacherova

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic
⨯

Ketogenic diet–induced changes in hepatic drug metabolism with potential implications for ozanimod pharmacokinetics in mice

Veronika Frybortova,
Stefan Satka,
Lenka Jourova,
Pavel Anzenbacher,
Iveta Zapletalova,
Michal Kraus,
Klara Kostovcikova,
Miloslav Kverka,
Eva Anzenbacherova

Published: September 8, 2026
https://doi.org/10.1371/journal.pone.0357797

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