Nasal exposure to PM2.5 induces testicular injury and activation of pyroptosis-related signaling in rats: Inhibitor intervention and public transcriptomic analysis

Yi Luo; Cao Wang; Mengxi Tian; Guangyou Lang; Kaixin Li; Zhongyan Zhang; Yu Chu; Qing Xiao; Ma Hong

doi:10.1371/journal.pone.0357773

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Open Access

Peer-reviewed

Research Article

Nasal exposure to PM2.5 induces testicular injury and activation of pyroptosis-related signaling in rats: Inhibitor intervention and public transcriptomic analysis

Yi Luo ,

Contributed equally to this work with: Yi Luo, Cao Wang, Mengxi Tian

Roles Investigation, Methodology, Project administration

Affiliation Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China

https://orcid.org/0009-0000-6532-0388

⨯
Cao Wang ,

Contributed equally to this work with: Yi Luo, Cao Wang, Mengxi Tian

Roles Software, Supervision

Affiliation Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
⨯
Mengxi Tian ,

Contributed equally to this work with: Yi Luo, Cao Wang, Mengxi Tian

Roles Investigation, Methodology

Affiliation Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
⨯
Guangyou Lang,

Roles Project administration, Software

Affiliation Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
⨯
Kaixin Li,

Roles Investigation, Writing – original draft

Affiliation Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
⨯
Zhongyan Zhang,

Roles Formal analysis, Writing – review & editing

Affiliation Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
⨯
Yu Chu,

Roles Formal analysis, Visualization

Affiliation Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
⨯
Qing Xiao,

Roles Resources, Writing – review & editing

Affiliation Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
⨯
Ma Hong

Roles Conceptualization, Investigation, Project administration

* E-mail: 3903846352@qq.com

Affiliation Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China

https://orcid.org/0009-0000-4760-3851

⨯

Nasal exposure to PM2.5 induces testicular injury and activation of pyroptosis-related signaling in rats: Inhibitor intervention and public transcriptomic analysis

Yi Luo,
Cao Wang,
Mengxi Tian,
Guangyou Lang,
Kaixin Li,
Zhongyan Zhang,
Yu Chu,
Qing Xiao,
Ma Hong

Published: September 15, 2026
https://doi.org/10.1371/journal.pone.0357773

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