Clinical efficacy of empiric antibiotic therapy in Chinese patients with cirrhosis and bacterial infections: A multicenter study

Liqin Sheng; Xiuding Zhang; Haoda Weng; Qinzhi Deng; Min Deng; Xuwei Wu; Zuxiong Huang; Shourong Liu; Rui Wu; Chunlian Ma; Yao Xu; Jianfeng Zhong; Jie Yang; Yinxia Wu; Huajiang Shen; Feng Ding; Fang Wang; Xuezhen Zhai; Chunxian Peng; Haotang Ren; Jie Jin; Xiangfei Xu; Xiaofei Li; Xiaoting Ye; Guoqing Qian; Shuilin Sun; Xuebing Yao; Haifeng Miao; Qianggu Xiao; Shaoheng Ye; Qing Zhang; Xinyi Xu; Xianbin Xu; Yue Yu; Huilan Tu; Xinrong Zhang; Rui Huang; Qiao Yang; Jifang Sheng; Yu Shi; Xia Yu

doi:10.1371/journal.pone.0357491

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Open Access

Peer-reviewed

Research Article

Clinical efficacy of empiric antibiotic therapy in Chinese patients with cirrhosis and bacterial infections: A multicenter study

Liqin Sheng ,

Roles Data curation, Investigation, Methodology, Writing – original draft

¶☯ These authors contributed equally to this work and share first authorship.

Affiliation Haiyan People’s Hospital, Jiaxing, Zhejiang, China
⨯
Xiuding Zhang ,

Roles Data curation, Formal analysis, Writing – original draft

¶☯ These authors contributed equally to this work and share first authorship.

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Haoda Weng,

Roles Data curation

Affiliation Hangzhou First People's Hospital Tonglu Hospital, Hangzhou, China
⨯
Qinzhi Deng,

Roles Data curation

Affiliation Department of Infectious Diseases, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China
⨯
Min Deng,

Roles Data curation

Affiliation Department of Infectious Diseases, Affiliated Hospital of Jiaxing University/The First Hospital of Jiaxing, Jiaxing, Zhejiang, China
⨯
Xuwei Wu,

Roles Data curation

Affiliation Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, China
⨯
Zuxiong Huang,

Roles Data curation

Affiliation Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, China
⨯
Shourong Liu,

Roles Data curation

Affiliation Department of Infectious Diseases, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
⨯
Rui Wu,

Roles Data curation

Affiliation Department of Infectious Diseases, The First People's Hospital of Wenling, Taizhou, Zhejiang, China
⨯
Chunlian Ma,

Roles Data curation

Affiliation Department of Infectious Diseases, The First People's Hospital of Wenling, Taizhou, Zhejiang, China
⨯
Yao Xu,

Roles Data curation

Affiliation Linyi People's Hospital, Linyi, Shandong, China
⨯
Jianfeng Zhong,

Roles Data curation

Affiliation Department of Infectious Diseases, Huzhou Central Hospital, Huzhou, Zhejiang, China
⨯
Jie Yang,

Roles Data curation

Affiliation Department of Infectious Diseases, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China
⨯
Yinxia Wu,

Roles Data curation

Affiliation Department of Infectious Diseases, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China
⨯
Huajiang Shen,

Roles Data curation

Affiliation Department of Infectious Diseases, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China
⨯
Feng Ding,

Roles Data curation

Affiliation Department of Infectious Diseases, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China
⨯
Fang Wang,

Roles Data curation

Affiliation Department of Infectious Diseases, Beilun District People's Hospital, Ningbo, Zhejiang, China
⨯
Xuezhen Zhai,

Roles Data curation

Affiliation The Fifth People's Hospital of Huaian, Huaian, Jiangsu, China
⨯
Chunxian Peng,

Roles Data curation

Affiliation Department of Infectious Diseases, Quzhou People's Hospital, Quzhou, Zhejiang, China
⨯
Haotang Ren,

Roles Data curation

Affiliation Weifang People's Hospital, Weifang, Shandong, China
⨯
Jie Jin,

Roles Data curation

Affiliation Department of Infectious Diseases, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, China
⨯
Xiangfei Xu,

Roles Data curation

Affiliation Department of Infectious Diseases, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, China
⨯
Xiaofei Li,

Roles Data curation

Affiliation Department of Infectious Diseases, Yiwu Central Hospital, Yiwu, Zhejiang, China
⨯
Xiaoting Ye,

Roles Data curation

Affiliation Department of Infectious Diseases, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Guoqing Qian,

Roles Data curation

Affiliation Department of Infectious Diseases, Ningbo First Hospital, Ningbo, Zhejiang, China
⨯
Shuilin Sun,

Roles Data curation

Affiliation The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
⨯
Xuebing Yao,

Roles Data curation

Affiliation The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
⨯
Haifeng Miao,

Roles Data curation

Affiliation Department of Infectious Diseases, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China
⨯
Qianggu Xiao,

Roles Data curation

Affiliation Department of Infectious Diseases, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China
⨯
Shaoheng Ye,

Roles Data curation

Affiliation Dongguan Ninth People's Hospital, Dongguan Infectious Diseases Hospital, Dongguan, Guangdong, China
⨯
Qing Zhang,

Roles Data curation

Affiliation Department of Gastroenterology, First Hospital of Yangtze University, Jingzhou, Hubei, China
⨯
Xinyi Xu,

Roles Data curation, Resources

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Xianbin Xu,

Roles Data curation, Resources

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Yue Yu,

Roles Data curation

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Huilan Tu,

Roles Data curation, Methodology

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Xinrong Zhang,

Roles Data curation, Supervision

Affiliation Gastroenterology and Hepatology, School of Medicine, Stanford University Medical Center, Palo Alto, California, United States of America
⨯
Rui Huang,

Roles Data curation, Formal analysis

Affiliation Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China
⨯
Qiao Yang,

Roles Data curation

Affiliations Department of Infectious Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, Department of Infectious Diseases, Sir Run Run Shaw Alaer Hospital, School of Medicine, Zhejiang University, Alaer, Xinjiang, China
⨯
Jifang Sheng,

Roles Validation, Writing – review & editing

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Yu Shi ,

Roles Funding acquisition, Supervision, Validation, Writing – review & editing

* E-mail: zjuyuxia@zju.edu.cn (XY); zjushiyu@zju.edu.cn (YS)

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

https://orcid.org/0000-0002-9392-7176

⨯
[ ... ],
Xia Yu

Roles Conceptualization, Supervision, Validation, Writing – review & editing

* E-mail: zjuyuxia@zju.edu.cn (XY); zjushiyu@zju.edu.cn (YS)

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

https://orcid.org/0000-0002-9779-9837

⨯
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Clinical efficacy of empiric antibiotic therapy in Chinese patients with cirrhosis and bacterial infections: A multicenter study

Liqin Sheng,
Xiuding Zhang,
Haoda Weng,
Qinzhi Deng,
Min Deng,
Xuwei Wu,
Zuxiong Huang,
Shourong Liu,
Rui Wu,
Chunlian Ma

Published: September 15, 2026
https://doi.org/10.1371/journal.pone.0357491

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Antibiotics
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Systemic inflammatory response syndrome
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Cirrhosis
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Chinese people
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