Integrative proteomics reveals MSH6 to modulate PARP inhibitor sensitivity in BRCA1/2-proficient ovarian cancer

• Ou Deng ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: uwe.rix@moffitt.org (UR), alvaro.monteiro@moffitt.org (ANM), ou.deng@moffitt.org (OD)

  Affiliation Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America

  https://orcid.org/0000-0002-9933-1832

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• Thales Da Costa Nepomuceno,

  Roles Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America

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• Bin Fang,

  Roles Data curation, Investigation, Methodology, Resources, Visualization

  Affiliation Proteomics & Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America

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• Eric A. Welsh,

  Roles Data curation, Formal analysis, Methodology, Resources, Software

  Affiliation Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America

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• Victoria Izumi,

  Roles Investigation, Methodology

  Affiliation Proteomics & Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America

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• Rachael H. Martin,

  Roles Resources, Visualization

  Affiliation Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America

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• Erin M. George,

  Roles Conceptualization, Methodology, Resources, Visualization

  Affiliation Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

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• John M. Koomen,

  Roles Methodology, Visualization, Writing – review & editing

  Affiliations Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America, Department of Molecular Biosciences, University of South Florida, Tampa, Florida, United States of America

  https://orcid.org/0000-0002-3818-1762

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• Alvaro N. Monteiro ,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: uwe.rix@moffitt.org (UR), alvaro.monteiro@moffitt.org (ANM), ou.deng@moffitt.org (OD)

  Affiliations Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America, Department of Molecular Biosciences, University of South Florida, Tampa, Florida, United States of America

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• Uwe Rix

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: uwe.rix@moffitt.org (UR), alvaro.monteiro@moffitt.org (ANM), ou.deng@moffitt.org (OD)

  Affiliations Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States of America, Department of Molecular Biosciences, University of South Florida, Tampa, Florida, United States of America

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