Integrated transcriptomic profiling implicates MAPK14/p38α as a candidate shared molecular target at the sepsis–postoperative delirium interface with computational evidence for a losartan–MAPK14 association

Wei-Jia Kong; Jing-Xian Xue; Lei Yu; Qing-Shan Zhou; Huai-Qi Zhang; Jun Jin; Jiang-Tao Deng

doi:10.1371/journal.pone.0357109

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Open Access

Peer-reviewed

Research Article

Integrated transcriptomic profiling implicates MAPK14/p38α as a candidate shared molecular target at the sepsis–postoperative delirium interface with computational evidence for a losartan–MAPK14 association

Wei-Jia Kong,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliation Department of Critical Care Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
⨯
Jing-Xian Xue,

Roles Data curation, Validation, Writing – review & editing

Affiliation Department of Critical Care Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
⨯
Lei Yu,

Roles Investigation, Resources, Writing – review & editing

Affiliation Department of Critical Care Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
⨯
Qing-Shan Zhou,

Roles Investigation, Resources, Writing – review & editing

Affiliation Department of Critical Care Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
⨯
Huai-Qi Zhang ,

Roles Resources, Validation, Writing – review & editing

* E-mail: lopdeng005@gmail.com (JTD); jinj@hku-szh.org (JJ); zhanghq35@mailsysu.edu.cn (HQZ)

Affiliation Department of Pain Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China
⨯
Jun Jin ,

Roles Visualization, Writing – review & editing

* E-mail: lopdeng005@gmail.com (JTD); jinj@hku-szh.org (JJ); zhanghq35@mailsysu.edu.cn (HQZ)

Affiliation Department of Critical Care Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
⨯
Jiang-Tao Deng

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: lopdeng005@gmail.com (JTD); jinj@hku-szh.org (JJ); zhanghq35@mailsysu.edu.cn (HQZ)

Affiliation Department of Critical Care Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China

https://orcid.org/0009-0003-5340-229X

⨯

Integrated transcriptomic profiling implicates MAPK14/p38α as a candidate shared molecular target at the sepsis–postoperative delirium interface with computational evidence for a losartan–MAPK14 association

Wei-Jia Kong,
Jing-Xian Xue,
Lei Yu,
Qing-Shan Zhou,
Huai-Qi Zhang,
Jun Jin,
Jiang-Tao Deng

Published: August 26, 2026
https://doi.org/10.1371/journal.pone.0357109

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Sepsis
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Transcriptome analysis
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Gene expression
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STAT signaling
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