Supporting clinical guidelines for opioid conversion to methadone and tapering to prevent withdrawal in critically ill children using physiology based pharmacokinetic modeling and simulation

• Marika A. de Hoop-Sommen ,

  Contributed equally to this work with: Marika A. de Hoop-Sommen, Sahar Alozai

  Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft

  Affiliation Department of Pharmacy, Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands

  https://orcid.org/0000-0003-1923-2111

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• Sahar Alozai ,

  Contributed equally to this work with: Marika A. de Hoop-Sommen, Sahar Alozai

  Roles Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliation Royal Dutch Pharmacy Association (KNMP), Medicines Information Centre (GIC), The Hague, The Netherlands

  https://orcid.org/0009-0000-0732-7012

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• Violette M. G. J. Gijsen,

  Roles Writing – review & editing

  Affiliation Department of Pharmacy, Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands

  https://orcid.org/0009-0001-3144-9359

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• Tjitske M. van der Zanden,

  Roles Writing – review & editing

  Affiliations Department of Pharmacy, Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands, Dutch Knowledge Centre Pharmacotherapy for Children, Rotterdam, The Netherlands, Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive care, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands

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• Henry T. Akinbi,

  Roles Writing – review & editing

  Affiliations Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• Tomoyuki Mizuno,

  Roles Writing – review & editing

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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• Alexander A. Vinks,

  Roles Writing – review & editing

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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• Rick Greupink,

  Roles Conceptualization, Supervision

  Affiliation Department of Pharmacy, Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands

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• Saskia N. de Wildt

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: Saskia.deWildt@radboudumc.nl

  Affiliations Department of Pharmacy, Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands, Dutch Knowledge Centre Pharmacotherapy for Children, Rotterdam, The Netherlands, Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive care, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands

  https://orcid.org/0000-0002-0502-0647

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