Identification and validation of oxidative stress-related immune signatures in Hepatitis B Virus associated acute liver failure based on WGCNA and machine learning

Lu Dai; Jungang Tan; Zhimin Zhou; Chengcong Chen; Guoxin Hu; Ling Guo

doi:10.1371/journal.pone.0356638

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Open Access

Peer-reviewed

Research Article

Identification and validation of oxidative stress-related immune signatures in Hepatitis B Virus associated acute liver failure based on WGCNA and machine learning

Lu Dai ,

Contributed equally to this work with: Lu Dai, Jungang Tan

Roles Visualization, Writing – original draft

Affiliations Department of Infectious Diseases, Peking University Shenzhen hospital, Shenzhen, China, Clinical Institute of Anhui Medical University & Peking University Shenzhen hospital, Shenzhen, China
⨯
Jungang Tan ,

Contributed equally to this work with: Lu Dai, Jungang Tan

Roles Data curation, Methodology, Visualization

Affiliation Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China
⨯
Zhimin Zhou,

Roles Data curation

Affiliation Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China
⨯
Chengcong Chen,

Roles Funding acquisition, Writing – review & editing

Affiliation Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China
⨯
Guoxin Hu ,

Roles Conceptualization, Formal analysis

* E-mail: biya102@163.com (LG); 3823608228@163.com (GH)

Affiliations Department of Infectious Diseases, Peking University Shenzhen hospital, Shenzhen, China, Clinical Institute of Anhui Medical University & Peking University Shenzhen hospital, Shenzhen, China
⨯
Ling Guo

Roles Funding acquisition, Writing – review & editing

* E-mail: biya102@163.com (LG); 3823608228@163.com (GH)

Affiliation Department of Infectious Diseases, Peking University Shenzhen hospital, Shenzhen, China

https://orcid.org/0009-0008-6197-5983

⨯

Identification and validation of oxidative stress-related immune signatures in Hepatitis B Virus associated acute liver failure based on WGCNA and machine learning

Lu Dai,
Jungang Tan,
Zhimin Zhou,
Chengcong Chen,
Guoxin Hu,
Ling Guo

Published: September 9, 2026
https://doi.org/10.1371/journal.pone.0356638

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Biomarkers
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Immune cells
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Oxidative stress
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Acute liver failure
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