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Efficacy and safety of 15 mA transcranial alternating current stimulation (tACS) in the therapy of treatment-resistant depression with increased inflammatory activity: Study protocol for a randomized, double-blind, sham-controlled trial

Xuguang An ,

Contributed equally to this work with: Xuguang An, Jin Zhang

Roles Methodology, Project administration, Writing – original draft

¶☯ The two authors share the first authorship

Affiliation Tianjin Anding Hospital, Tianjin Mental Health Center, Hexi District, Tianjin, China
⨯
Jin Zhang ,

Contributed equally to this work with: Xuguang An, Jin Zhang

Roles Methodology, Project administration, Writing – original draft

¶☯ The two authors share the first authorship

Affiliation Tianjin Anding Hospital, Tianjin Mental Health Center, Hexi District, Tianjin, China
⨯
Xiaofei Hou,

Roles Data curation, Formal analysis

Affiliation Tianjin Anding Hospital, Tianjin Mental Health Center, Hexi District, Tianjin, China
⨯
Chenghao Yang

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: yangchh@tjmhc.com

Affiliation Tianjin Anding Hospital, Tianjin Mental Health Center, Hexi District, Tianjin, China

https://orcid.org/0000-0002-3424-6004

⨯

Efficacy and safety of 15 mA transcranial alternating current stimulation (tACS) in the therapy of treatment-resistant depression with increased inflammatory activity: Study protocol for a randomized, double-blind, sham-controlled trial

Xuguang An,
Jin Zhang,
Xiaofei Hou,
Chenghao Yang

x

Published: August 27, 2026
https://doi.org/10.1371/journal.pone.0356611

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Antidepressant drug therapy
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Depression
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Antidepressants
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Inflammation
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Transcranial alternating current stimulation
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Electroencephalography
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Adverse events
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