Evaluating the impact of segmentation strategies on radiomic feature stability for paediatric brain tumour diagnosis using diffusion weighted imaging

Timothy Mulvany; Daniel Griffiths-King; Lara Worthington; Katherine Crombie; Heather E. L. Rose; Andrew Peet; John Apps; Jan Novak

doi:10.1371/journal.pone.0356382

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Open Access

Peer-reviewed

Research Article

Evaluating the impact of segmentation strategies on radiomic feature stability for paediatric brain tumour diagnosis using diffusion weighted imaging

Timothy Mulvany,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Aston Institute of Health and Neurodevelopment, Aston University, Birmingham, United Kingdom

https://orcid.org/0009-0000-1699-4415

⨯
Daniel Griffiths-King,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation Aston Institute of Health and Neurodevelopment, Aston University, Birmingham, United Kingdom
⨯
Lara Worthington,

Roles Data curation, Writing – review & editing

Affiliation Department of Oncology, Birmingham Women’s and Children’s Hospital NHS Foundation Trust, Birmingham, United Kingdom
⨯
Katherine Crombie,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Institute of Cancer & Genomics Science, University of Birmingham, Birmingham, United Kingdom

https://orcid.org/0009-0006-4405-7561

⨯
Heather E. L. Rose,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Medical Physics Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, School of Medicine, University of Nottingham, Nottingham, United Kingdom

https://orcid.org/0000-0002-0346-1334

⨯
Andrew Peet,

Roles Conceptualization, Writing – review & editing

Affiliations Department of Oncology, Birmingham Women’s and Children’s Hospital NHS Foundation Trust, Birmingham, United Kingdom, Institute of Cancer & Genomics Science, University of Birmingham, Birmingham, United Kingdom
⨯
John Apps,

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliations Department of Oncology, Birmingham Women’s and Children’s Hospital NHS Foundation Trust, Birmingham, United Kingdom, Institute of Cancer & Genomics Science, University of Birmingham, Birmingham, United Kingdom
⨯
Jan Novak

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: j.novak@aston.ac.uk

Affiliation Aston Institute of Health and Neurodevelopment, Aston University, Birmingham, United Kingdom

https://orcid.org/0000-0001-5173-3608

⨯

Evaluating the impact of segmentation strategies on radiomic feature stability for paediatric brain tumour diagnosis using diffusion weighted imaging

Timothy Mulvany,
Daniel Griffiths-King,
Lara Worthington,
Katherine Crombie,
Heather E. L. Rose,
Andrew Peet,
John Apps,
Jan Novak

Published: August 18, 2026
https://doi.org/10.1371/journal.pone.0356382

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