Orchestration of kaempferol nuclear translocation by phase ii metabolic enzymes and efflux transporters suppresses colorectal cancer

Chishun Zhou; Qing Ning; Xin Jin; Yu Li; Yuefang Lin; Jiarun Lin; Jing Zheng; Yukai Huang; Wei Wang; Zhongqiu Liu; Linlin Lu

doi:10.1371/journal.pone.0355962

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Open Access

Peer-reviewed

Research Article

Orchestration of kaempferol nuclear translocation by phase ii metabolic enzymes and efflux transporters suppresses colorectal cancer

Chishun Zhou ,

Contributed equally to this work with: Chishun Zhou, Qing Ning

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong Hengqin, China; and Guangdong Provincial Key Laboratory of Translational Chinese Medicine, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Qing Ning ,

Contributed equally to this work with: Chishun Zhou, Qing Ning

Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – original draft

Affiliation Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Xin Jin,

Roles Data curation, Funding acquisition, Resources, Supervision, Conceptualization

Affiliation Department of Colorectal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, China
⨯
Yu Li,

Roles Conceptualization, Methodology, Software, Validation, Visualization

Affiliation Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong Hengqin, China; and Guangdong Provincial Key Laboratory of Translational Chinese Medicine, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Yuefang Lin,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software

Affiliation Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong Hengqin, China; and Guangdong Provincial Key Laboratory of Translational Chinese Medicine, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Jiarun Lin,

Roles Data curation, Investigation, Methodology

Affiliation Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong Hengqin, China; and Guangdong Provincial Key Laboratory of Translational Chinese Medicine, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Jing Zheng,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

Current address: School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, Guangdong Province, China

Affiliation Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong Hengqin, China; and Guangdong Provincial Key Laboratory of Translational Chinese Medicine, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Yukai Huang,

Roles Conceptualization, Data curation, Investigation, Methodology

Affiliation Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong Hengqin, China; and Guangdong Provincial Key Laboratory of Translational Chinese Medicine, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Wei Wang ,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Resources

* E-mail: lllu@gzucm.edu.cn (LL); liuzq@gzucm.edu.cn (ZL); wangwei16400@163.com (WW)

Affiliation Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, China
⨯
Zhongqiu Liu ,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Resources, Supervision, Visualization

* E-mail: lllu@gzucm.edu.cn (LL); liuzq@gzucm.edu.cn (ZL); wangwei16400@163.com (WW)

Affiliation Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong Hengqin, China; and Guangdong Provincial Key Laboratory of Translational Chinese Medicine, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Linlin Lu

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

* E-mail: lllu@gzucm.edu.cn (LL); liuzq@gzucm.edu.cn (ZL); wangwei16400@163.com (WW)

Affiliation Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong Hengqin, China; and Guangdong Provincial Key Laboratory of Translational Chinese Medicine, Joint International Research Laboratory of Translational Cancer Research of Chinese Medicines, State Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

https://orcid.org/0000-0002-8221-4613

⨯

Orchestration of kaempferol nuclear translocation by phase ii metabolic enzymes and efflux transporters suppresses colorectal cancer

Chishun Zhou,
Qing Ning,
Xin Jin,
Yu Li,
Yuefang Lin,
Jiarun Lin,
Jing Zheng,
Yukai Huang,
Wei Wang,
Zhongqiu Liu

Published: September 15, 2026
https://doi.org/10.1371/journal.pone.0355962

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