Feasibility, safety, and preliminary clinical efficacy of resting-state functional connectivity MRI-guided rTMS for adolescents with major depressive disorder: Protocol for a randomized, double-blind, three-arm, sham-controlled pilot trial

Hongyi Chen; Danyu Xu; Wenjing Wang; Xinyin Luo; Xiaocong Jiang; Ningyi Wan; Yuhuan Wei; Ting Wang; Li Zhang; Xuemei Li; Xinyu Zhou

doi:10.1371/journal.pone.0355676

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Feasibility, safety, and preliminary clinical efficacy of resting-state functional connectivity MRI-guided rTMS for adolescents with major depressive disorder: Protocol for a randomized, double-blind, three-arm, sham-controlled pilot trial

Hongyi Chen ,

Roles Conceptualization, Methodology, Writing – original draft

¶☯ These authors contributed equally to the manuscript.

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Danyu Xu ,

Roles Conceptualization, Methodology, Writing – review & editing

¶☯ These authors contributed equally to the manuscript.

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Wenjing Wang,

Roles Investigation

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Xinyin Luo,

Roles Methodology

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Xiaocong Jiang,

Roles Investigation

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Ningyi Wan,

Roles Methodology

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Yuhuan Wei,

Roles Data curation, Investigation

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Ting Wang,

Roles Data curation, Investigation

Affiliation Department of Psychology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Li Zhang,

Roles Data curation, Investigation

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Xuemei Li ,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: zhouxinyu@cqmu.edu.cn (XZ); xuemeililucky@126.com (XL)

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Xinyu Zhou

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: zhouxinyu@cqmu.edu.cn (XZ); xuemeililucky@126.com (XL)

Affiliation Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

https://orcid.org/0000-0002-8241-2636

⨯

Feasibility, safety, and preliminary clinical efficacy of resting-state functional connectivity MRI-guided rTMS for adolescents with major depressive disorder: Protocol for a randomized, double-blind, three-arm, sham-controlled pilot trial

Hongyi Chen,
Danyu Xu,
Wenjing Wang,
Xinyin Luo,
Xiaocong Jiang,
Ningyi Wan,
Yuhuan Wei,
Ting Wang,
Li Zhang,
Xuemei Li

Published: August 6, 2026
https://doi.org/10.1371/journal.pone.0355676

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