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Open Access
Peer-reviewed
Research Article
HIF-1α inhibits the TLR4/NF-κB signaling pathway and modulates intestinal flora in diarrhea-predominant irritable bowel syndrome
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Xing He ,
Contributed equally to this work with: Xing He, Dechun Wang
Roles Formal analysis, Funding acquisition, Methodology
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Dechun Wang ,
Contributed equally to this work with: Xing He, Dechun Wang
Roles Conceptualization, Data curation, Formal analysis
Affiliation Department of Gastroenterology, General Hospital of Xizang Military Command, Lhasa, Xizang, China
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Bin Yang,
Roles Data curation, Software, Writing – original draft
Affiliation The Third Stationed Outpatient Department, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Hezhong Yan,
Roles Formal analysis, Methodology, Supervision
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Honglin Ma,
Roles Methodology, Software, Writing – original draft
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Haiqing Li,
Roles Data curation, Investigation, Methodology
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Jiaoxue Wang,
Roles Data curation, Investigation, Methodology
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Qian Gao,
Roles Data curation, Investigation, Methodology
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Senyuan Yu,
Roles Investigation, Methodology, Software
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Xilu Hou,
Roles Data curation, Software, Validation
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Shicun Guo,
Roles Data curation, Formal analysis, Investigation
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Guobin Liao,
Roles Investigation, Methodology, Software
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Xiaowei Duan ,
Roles Data curation, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: 13956908600@163.com
¶‡ XD and JT also contributed equally to this work.
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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Jun Tang
Roles Conceptualization, Resources, Writing – original draft, Writing – review & editing
* E-mail: 13956908600@163.com
¶‡ XD and JT also contributed equally to this work.
Affiliation Department of Gastroenterology, 901st Hospital of the PLA Joint Logistics Support Force, Hefei, Anhui Province, China
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HIF-1α inhibits the TLR4/NF-κB signaling pathway and modulates intestinal flora in diarrhea-predominant irritable bowel syndrome
- Xing He,
- Dechun Wang,
- Bin Yang,
- Hezhong Yan,
- Honglin Ma,
- Haiqing Li,
- Jiaoxue Wang,
- Qian Gao,
- Senyuan Yu,
- Xilu Hou
- Published: August 6, 2026
- https://doi.org/10.1371/journal.pone.0355467