A bioactivity-leveling approach for component-specific evaluation in natural product extracts: Optimizing SARS-CoV-2 antiviral screening by controlling for pheophorbide A

• Corinna Urmann ,

  Roles Conceptualization, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: corinna.urmann@hswt.de, corinna.urmann@tum.de

  Affiliations Organic-analytical Chemistry, Weihenstephan-Triesdorf University of Applied Sciences, Straubing, Germany, TUM Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany

  https://orcid.org/0000-0001-8895-9416

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• Yvonne Gmach,

  Roles Investigation, Visualization, Writing – original draft

  Affiliations Organic-analytical Chemistry, Weihenstephan-Triesdorf University of Applied Sciences, Straubing, Germany, TUM Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany

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• Niklas Hofer,

  Roles Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliations Organic-analytical Chemistry, Weihenstephan-Triesdorf University of Applied Sciences, Straubing, Germany, TUM Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany

  https://orcid.org/0009-0008-1429-6865

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• Nina Vahekeni,

  Roles Investigation, Project administration

  Affiliation Natural Product Chemistry and Phytopharmacy Group, Institute of Chemistry and Biotechnology, School of Life Sciences and Facility Management, ZHAW Zurich University of Applied Sciences, Wädenswil, Switzerland

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• Jonas Stehlin,

  Roles Investigation, Writing – review & editing

  Affiliation Natural Product Chemistry and Phytopharmacy Group, Institute of Chemistry and Biotechnology, School of Life Sciences and Facility Management, ZHAW Zurich University of Applied Sciences, Wädenswil, Switzerland

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• Yannick Geissmann,

  Roles Investigation

  Affiliation Spiez Laboratory, Federal Office for Civil Protection, Spiez, Switzerland

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• Andreas Lardos,

  Roles Project administration, Supervision, Writing – review & editing

  Affiliation Natural Product Chemistry and Phytopharmacy Group, Institute of Chemistry and Biotechnology, School of Life Sciences and Facility Management, ZHAW Zurich University of Applied Sciences, Wädenswil, Switzerland

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• Olivier Engler,

  Roles Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Spiez Laboratory, Federal Office for Civil Protection, Spiez, Switzerland

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• Evelyn Wolfram

  Roles Supervision, Writing – original draft, Writing – review & editing

  Affiliation Natural Product Chemistry and Phytopharmacy Group, Institute of Chemistry and Biotechnology, School of Life Sciences and Facility Management, ZHAW Zurich University of Applied Sciences, Wädenswil, Switzerland

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