Guazuma ulmifolia butanol extract protects against cadmium-induced hepatotoxicity via HO-1/Sirt-1 activation, miRNA–lncRNA modulation, and metabolic reprogramming

• Osama Ahmed Elsabagh ,

  Contributed equally to this work with: Osama Ahmed Elsabagh, Abdelbaset M. Elgamal, Heba A. Hassan, Naglaa M. Ammar

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Pharmacognosy Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), Cairo, Egypt

  ⨯
• Abdelbaset M. Elgamal ,

  Contributed equally to this work with: Osama Ahmed Elsabagh, Abdelbaset M. Elgamal, Heba A. Hassan, Naglaa M. Ammar

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry of Microbial and Natural Products, Pharmaceutical and Drugs Research Institute, National Research Centre, Giza, Egypt

  ⨯
• Heba A. Hassan ,

  Contributed equally to this work with: Osama Ahmed Elsabagh, Abdelbaset M. Elgamal, Heba A. Hassan, Naglaa M. Ammar

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Therapeutic Chemistry Department, National Research Centre, Dokki, Giza, Egypt

  ⨯
• Naglaa M. Ammar ,

  Contributed equally to this work with: Osama Ahmed Elsabagh, Abdelbaset M. Elgamal, Heba A. Hassan, Naglaa M. Ammar

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Therapeutic Chemistry Department, National Research Centre, Dokki, Giza, Egypt

  ⨯
• Zeinab A. El-Gendy,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt

  ⨯
• Mohamed A. El-Saied,

  Roles Investigation, Methodology, Writing – original draft

  Affiliations Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt, Department of Pathology, Faculty of Veterinary Medicine, King Salman International University (KSIU)

  ⨯
• Mawada Mohamed Ali,

  Roles Investigation, Methodology

  Affiliation Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

  ⨯
• Reham S. Ibrahim,

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Egypt

  ⨯
• Ahmed H. El-Desoky,

  Roles Formal analysis, Methodology

  Affiliation Pharmacognosy Department, National Research Center, Dokki, Giza, Egypt

  ⨯
• Emad M. Hassan,

  Roles Investigation, Methodology

  Affiliation Medicinal and Aromatic Plants Research Department, National Research Centre, Dokki, Giza, Egypt

  ⨯
• Mohamed A. Farag,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

  ⨯
• Abdelsamed I. Elshamy

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  * E-mail: elshamynrc@yahoo.com, ai.el-shamy@nrc.sci.eg

  Affiliation Department of Natural Compounds Chemistry, National Research Centre, Dokki, Giza, Egypt

  https://orcid.org/0000-0003-3302-3623

  ⨯