Cross-serotype immunity elicited by a consensus dengue NS1 mRNA vaccine in mice

Kittipan Tharakhet; Eakachai Prompetchara; Chirayus Khawsang; Supichcha Saithong; Papatsara Kaewpang; Nongnaphat Yostrerat; Pachara Wangsoontorn; Jenjira Sontikun; Sawaros Tantratorn; Thidarat Khotprathum; Kieu Lam; James Heyes; Drew Weissman; Kiat Ruxrungtham; Chutitorn Ketloy

doi:10.1371/journal.pone.0355389

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Open Access

Peer-reviewed

Research Article

Cross-serotype immunity elicited by a consensus dengue NS1 mRNA vaccine in mice

Kittipan Tharakhet ,

Contributed equally to this work with: Kittipan Tharakhet, Eakachai Prompetchara

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliations Medical Sciences of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Eakachai Prompetchara ,

Contributed equally to this work with: Kittipan Tharakhet, Eakachai Prompetchara

Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – review & editing

Affiliations Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Chirayus Khawsang,

Roles Investigation, Methodology, Validation

Affiliation Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Supichcha Saithong,

Roles Investigation, Methodology

Affiliation Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Papatsara Kaewpang,

Roles Investigation

Affiliation Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Nongnaphat Yostrerat,

Roles Investigation

Affiliation Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Pachara Wangsoontorn,

Roles Investigation

Affiliation Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0009-0005-6162-724X

⨯
Jenjira Sontikun,

Roles Investigation

Affiliation Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Sawaros Tantratorn,

Roles Investigation

Affiliation Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Thidarat Khotprathum,

Roles Investigation

Affiliation Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Kieu Lam,

Roles Methodology

Affiliation Genevant Sciences Corporation, Vancouver, Canada
⨯
James Heyes,

Roles Methodology

Affiliation Genevant Sciences Corporation, Vancouver, Canada
⨯
Drew Weissman,

Roles Conceptualization, Supervision

Affiliation Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Kiat Ruxrungtham,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, School of Global Health, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Chutitorn Ketloy

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: chutitorn.k@chula.ac.th

Affiliations Center of Excellence in Vaccine Research and Development (Chula VRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0000-0002-7043-8062

⨯

Cross-serotype immunity elicited by a consensus dengue NS1 mRNA vaccine in mice

Kittipan Tharakhet,
Eakachai Prompetchara,
Chirayus Khawsang,
Supichcha Saithong,
Papatsara Kaewpang,
Nongnaphat Yostrerat,
Pachara Wangsoontorn,
Jenjira Sontikun,
Sawaros Tantratorn,
Thidarat Khotprathum

Published: August 6, 2026
https://doi.org/10.1371/journal.pone.0355389

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