A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing

• Qin Meng,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft

  Affiliations Academy of Pharmacy, Xi’an Jiaotong-Liverpool University, Suzhou, China, Department of Analytical Science, Shanghai Junshi Biosciences Co., Ltd., Shanghai, China

  https://orcid.org/0009-0007-2345-2308

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• Xujia Wang,

  Roles Data curation, Formal analysis

  Affiliation Department of Analytical Science, Shanghai Junshi Biosciences Co., Ltd., Shanghai, China

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• Yuxuan Zhang,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Department of Analytical Science, Shanghai Junshi Biosciences Co., Ltd., Shanghai, China

  https://orcid.org/0000-0002-2747-1860

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• Sudeep Pushpakom,

  Roles Supervision, Writing – review & editing

  Affiliation Institute of Systems, Molecular & Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom

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• Jun Yang,

  Roles Supervision, Writing – review & editing

  Affiliation Academy of Pharmacy, Xi’an Jiaotong-Liverpool University, Suzhou, China

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• Hui Feng,

  Roles Supervision, Writing – review & editing

  Affiliation Reasearch & Development Department, Shanghai Anlingke Biopharmaceutical Co., Ltd., Shanghai, China

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• Mu Wang

  Roles Supervision, Writing – review & editing

  * E-mail: mu.wang@xjtlu.edu.cn

  Current address: Academy of Pharmacy, Xi’an Jiaotong-Liverpool University, 111 Ren’ai Road, SD334F, Suzhou 215123, Jiangsu, China.

  Affiliation Academy of Pharmacy, Xi’an Jiaotong-Liverpool University, Suzhou, China

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