Integrated computational analysis identifies FABP4, PTGS2, and HPGD as Key molecular targets linking PET microplastic exposure to metabolic dysfunction-associated steatotic liver disease

Yi Zhang; Yao Yu; Bin Ge; Dacai Gong; Lan Zheng; Yuanyi Wang; Peng Chen

doi:10.1371/journal.pone.0354607

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Open Access

Peer-reviewed

Research Article

Integrated computational analysis identifies FABP4, PTGS2, and HPGD as Key molecular targets linking PET microplastic exposure to metabolic dysfunction-associated steatotic liver disease

Yi Zhang ,

Roles Writing – original draft, Writing – review & editing

¶☯ Parallel first author

Affiliation Department of Clinical Laboratory, Pidu District People’s Hospital, The 3RD Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China
⨯
Yao Yu ,

Roles Methodology, Writing – original draft

¶☯ Parallel first author

Affiliation Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, China
⨯
Bin Ge,

Roles Conceptualization, Data curation

Affiliation Department of Clinical Laboratory, Pidu District People’s Hospital, The 3RD Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China
⨯
Dacai Gong,

Roles Investigation, Methodology

Affiliation Department of Clinical Laboratory, Pidu District People’s Hospital, The 3RD Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China
⨯
Lan Zheng,

Roles Methodology, Software

Affiliation Department of Clinical Laboratory, Pidu District People’s Hospital, The 3RD Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China
⨯
Yuanyi Wang,

Roles Resources, Software

Affiliation Department of Clinical Laboratory, Pidu District People’s Hospital, The 3RD Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China
⨯
Peng Chen

Roles Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: chenpeng12375@163.com

Affiliation Department of Clinical Laboratory, Pidu District People’s Hospital, The 3RD Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China

https://orcid.org/0009-0002-3311-1367

⨯

Integrated computational analysis identifies FABP4, PTGS2, and HPGD as Key molecular targets linking PET microplastic exposure to metabolic dysfunction-associated steatotic liver disease

Yi Zhang,
Yao Yu,
Bin Ge,
Dacai Gong,
Lan Zheng,
Yuanyi Wang,
Peng Chen

Published: July 24, 2026
https://doi.org/10.1371/journal.pone.0354607

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