A comprehensive full-length transcriptome landscape of cigarette smoke-exposed HASMCs reveals extensive remodeling of mRNA isoforms and regulatory networks

Wei Gou; Lei Yang; Shan Chen; Yulin Miao; Weiwei Wang; Hai Li; Zhipeng Hu

doi:10.1371/journal.pone.0354604

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Open Access

Peer-reviewed

Research Article

A comprehensive full-length transcriptome landscape of cigarette smoke-exposed HASMCs reveals extensive remodeling of mRNA isoforms and regulatory networks

Wei Gou ,

Contributed equally to this work with: Wei Gou, Lei Yang

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia, China
⨯
Lei Yang ,

Contributed equally to this work with: Wei Gou, Lei Yang

Roles Conceptualization, Formal analysis, Investigation, Software, Writing – original draft

Affiliation Department of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia, China
⨯
Shan Chen,

Roles Data curation, Investigation

Affiliation Department of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia, China
⨯
Yulin Miao,

Roles Formal analysis, Validation, Writing – review & editing

Affiliation Department of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia, China
⨯
Weiwei Wang,

Roles Software, Visualization

Affiliation Department of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia, China
⨯
Hai Li ,

Roles Project administration, Supervision

* E-mail: hzp345397581@163.com

Affiliation Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia, China
⨯
Zhipeng Hu

Roles Supervision, Writing – review & editing

* E-mail: hzp345397581@163.com

Affiliation Department of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan City, Ningxia, China

https://orcid.org/0009-0005-3927-058X

⨯

A comprehensive full-length transcriptome landscape of cigarette smoke-exposed HASMCs reveals extensive remodeling of mRNA isoforms and regulatory networks

Wei Gou,
Lei Yang,
Shan Chen,
Yulin Miao,
Weiwei Wang,
Hai Li,
Zhipeng Hu

Published: September 21, 2026
https://doi.org/10.1371/journal.pone.0354604

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