Selective GPR17 antagonism enhances structural and functional recovery in animal models of demyelination

• Dille De Herdt ,

  Contributed equally to this work with: Dille De Herdt, Evy Lefevere

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Rewind Therapeutics NV, Leuven (Heverlee), Belgium

  https://orcid.org/0009-0000-5916-987X

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• Evy Lefevere ,

  Contributed equally to this work with: Dille De Herdt, Evy Lefevere

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Validation, Writing – original draft, Writing – review & editing

  Affiliation Rewind Therapeutics NV, Leuven (Heverlee), Belgium

  ⨯
• Véronique Brouwers,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Rewind Therapeutics NV, Leuven (Heverlee), Belgium

  ⨯
• Line Hartvig,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Rewind Therapeutics NV, Leuven (Heverlee), Belgium

  ⨯
• Emiel Geeraerts,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Excelra, Ghent, Belgium

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• Cheng-Chih Hsiao,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliations Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, Netherlands, Department of Experimental Immunology, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam University Medical Center, Amsterdam, Netherlands

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• J. Q. Alida Chen,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, Netherlands

  https://orcid.org/0009-0001-2296-2396

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• Rui Pinto,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Rewind Therapeutics NV, Leuven (Heverlee), Belgium

  ⨯
• Guillaume Duvey,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Rewind Therapeutics NV, Leuven (Heverlee), Belgium

  ⨯
• Stephen Burbidge,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliation Rewind Therapeutics NV, Leuven (Heverlee), Belgium

  ⨯
• Anja Harmeier,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Rewind Therapeutics NV, Leuven (Heverlee), Belgium

  ⨯
• Irene Knuesel

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: irene.knuesel@rwdtx.com

  Affiliation Rewind Therapeutics NV, Leuven (Heverlee), Belgium

  https://orcid.org/0000-0003-0396-9952

  ⨯