Exploring the Role of Nesprin1 in isoproterenol-induced heart failure: Insights into pathogenesis and therapeutic implications

Qin Qin; Cenyuan Dong; Ziyi Zhou; Yangyuanzhi Liu; Mengpan Liu; Chunyu Cao; Lin Teng

doi:10.1371/journal.pone.0354482

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Open Access

Peer-reviewed

Research Article

Exploring the Role of Nesprin1 in isoproterenol-induced heart failure: Insights into pathogenesis and therapeutic implications

Qin Qin ,

Contributed equally to this work with: Qin Qin, Cenyuan Dong

Roles Writing – original draft

Affiliations Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China, Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang, China
⨯
Cenyuan Dong ,

Contributed equally to this work with: Qin Qin, Cenyuan Dong

Roles Writing – original draft

Affiliations Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China, Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang, China
⨯
Ziyi Zhou,

Roles Data curation

Affiliations Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China, Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang, China
⨯
Yangyuanzhi Liu,

Roles Software

Affiliations Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China, Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang, China
⨯
Mengpan Liu,

Roles Formal analysis, Writing – review & editing

Affiliations Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China, Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang, China
⨯
Chunyu Cao,

Roles Writing – review & editing

Affiliation School of Basic Medicine, China Three Gorges University, Yichang, Hubei, People’s Republic of China
⨯
Lin Teng

Roles Writing – review & editing

* E-mail: tenglin@ctgu.edu.cn

Affiliations Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, China, Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, China

https://orcid.org/0000-0003-4682-5692

⨯

Exploring the Role of Nesprin1 in isoproterenol-induced heart failure: Insights into pathogenesis and therapeutic implications

Qin Qin,
Cenyuan Dong,
Ziyi Zhou,
Yangyuanzhi Liu,
Mengpan Liu,
Chunyu Cao,
Lin Teng

Published: August 11, 2026
https://doi.org/10.1371/journal.pone.0354482

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