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Open Access
Study Protocol
The effect of a multimodal multicomponent Prehabilitation program in Older adults with Chronic limb-threatening Ischemia (POCI-study): A study protocol for a multicenter randomized controlled trial
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Seline Verbaan ,
Contributed equally to this work with: Seline Verbaan, Miriam C. Faes, Elke T. A. M. van Delft, Alexander L. Kooiman, Patrick W. H. E. Vriens, Hidde Jongsma, Ewout W. Steyerberg, Wilbert B. van den Hout, Lijckle van der Laan
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: sverbaan@amphia.nl
Affiliations Department of Surgery, Amphia Hospital, Breda, the Netherlands, TIAS school for business and society, Tilburg, the Netherlands
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Miriam C. Faes ,
Contributed equally to this work with: Seline Verbaan, Miriam C. Faes, Elke T. A. M. van Delft, Alexander L. Kooiman, Patrick W. H. E. Vriens, Hidde Jongsma, Ewout W. Steyerberg, Wilbert B. van den Hout, Lijckle van der Laan
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Geriatrics, Amphia Hospital, Breda, the Netherlands
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Elke T. A. M. van Delft ,
Contributed equally to this work with: Seline Verbaan, Miriam C. Faes, Elke T. A. M. van Delft, Alexander L. Kooiman, Patrick W. H. E. Vriens, Hidde Jongsma, Ewout W. Steyerberg, Wilbert B. van den Hout, Lijckle van der Laan
Roles Conceptualization, Funding acquisition, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Science Department, Amphia Hospital, Breda, the Netherlands
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Alexander L. Kooiman ,
Contributed equally to this work with: Seline Verbaan, Miriam C. Faes, Elke T. A. M. van Delft, Alexander L. Kooiman, Patrick W. H. E. Vriens, Hidde Jongsma, Ewout W. Steyerberg, Wilbert B. van den Hout, Lijckle van der Laan
Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Software, Validation, Writing – review & editing
Affiliations Department of Surgery, Amphia Hospital, Breda, the Netherlands, TIAS school for business and society, Tilburg, the Netherlands
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Patrick W. H. E. Vriens ,
Contributed equally to this work with: Seline Verbaan, Miriam C. Faes, Elke T. A. M. van Delft, Alexander L. Kooiman, Patrick W. H. E. Vriens, Hidde Jongsma, Ewout W. Steyerberg, Wilbert B. van den Hout, Lijckle van der Laan
Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing
Affiliations Department of Vascular Surgery, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands, Department of Medical & Clinical Psychology, Tilburg University, the Netherlands
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Hidde Jongsma ,
Contributed equally to this work with: Seline Verbaan, Miriam C. Faes, Elke T. A. M. van Delft, Alexander L. Kooiman, Patrick W. H. E. Vriens, Hidde Jongsma, Ewout W. Steyerberg, Wilbert B. van den Hout, Lijckle van der Laan
Roles Conceptualization, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing
Affiliation Department of Vascular Surgery, Meander Medical Centre, Amersfoort, the Netherlands
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Ewout W. Steyerberg ,
Contributed equally to this work with: Seline Verbaan, Miriam C. Faes, Elke T. A. M. van Delft, Alexander L. Kooiman, Patrick W. H. E. Vriens, Hidde Jongsma, Ewout W. Steyerberg, Wilbert B. van den Hout, Lijckle van der Laan
Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliation Julius Center for Health Sciences and primary care, University Medical Center Utrecht, Utrecht, the Netherlands
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Wilbert B. van den Hout ,
Contributed equally to this work with: Seline Verbaan, Miriam C. Faes, Elke T. A. M. van Delft, Alexander L. Kooiman, Patrick W. H. E. Vriens, Hidde Jongsma, Ewout W. Steyerberg, Wilbert B. van den Hout, Lijckle van der Laan
Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliation Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands
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Lijckle van der Laan ,
Contributed equally to this work with: Seline Verbaan, Miriam C. Faes, Elke T. A. M. van Delft, Alexander L. Kooiman, Patrick W. H. E. Vriens, Hidde Jongsma, Ewout W. Steyerberg, Wilbert B. van den Hout, Lijckle van der Laan
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Surgery, Amphia Hospital, Breda, the Netherlands, TIAS school for business and society, Tilburg, the Netherlands
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on behalf of the POCI-study group
¶Membership of the POCI-study group is provided in the Acknowledgments.
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The effect of a multimodal multicomponent Prehabilitation program in Older adults with Chronic limb-threatening Ischemia (POCI-study): A study protocol for a multicenter randomized controlled trial
- Seline Verbaan,
- Miriam C. Faes,
- Elke T. A. M. van Delft,
- Alexander L. Kooiman,
- Patrick W. H. E. Vriens,
- Hidde Jongsma,
- Ewout W. Steyerberg,
- Wilbert B. van den Hout,
- Lijckle van der Laan,
- on behalf of the POCI-study group
- Published: July 29, 2026
- https://doi.org/10.1371/journal.pone.0354344