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Open Access
Peer-reviewed
Research Article
High rates of SARS-CoV-2 reinfection in residents of long term care facilities despite robust spike-specific immunity following serial vaccination
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Gokhan Tut ,
Contributed equally to this work with: Gokhan Tut, Tara Lancaster, Laura Shallcross, Paul Moss
Roles Conceptualization, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Tara Lancaster ,
Contributed equally to this work with: Gokhan Tut, Tara Lancaster, Laura Shallcross, Paul Moss
Roles Conceptualization, Project administration, Writing – original draft, Writing – review & editing
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Panagiota Sylla,
Roles Investigation
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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David Bone,
Roles Investigation
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Christopher Bentley,
Roles Investigation
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Azar Jadir,
Roles Investigation
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Rachel Bruton,
Roles Project administration
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Katie Spencer,
Roles Investigation
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Soumyajit Mallick,
Roles Investigation
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Ahmed Elzaidi,
Roles Investigation
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Alexander Dowell,
Roles Investigation, Writing – review & editing
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Mary Wu,
Roles Investigation
Affiliation Covid Surveillance Unit, The Francis Crick Institute, London, United Kingdom
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Ruth Harvey,
Roles Investigation
Affiliation Worldwide Influenza Centre, The Francis Crick Institute London, London, United Kingdom
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Edward Carr,
Roles Investigation, Writing – review & editing
Affiliations The Francis Crick Institute London, London, United Kingdom, Genotype-to-Phenotype UK National Virology Consortium (G2P-UK), London, United Kingdom, UCL Department of Renal Medicine, Royal Free Hospital, London, United Kingdom
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Rupert Beale,
Roles Investigation, Writing – review & editing
Affiliations The Francis Crick Institute London, London, United Kingdom, Genotype-to-Phenotype UK National Virology Consortium (G2P-UK), London, United Kingdom, UCL Department of Renal Medicine, Royal Free Hospital, London, United Kingdom
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Maria Krutikov,
Roles Investigation, Validation, Writing – review & editing
Affiliation UCL Institute of Health Informatics, London, United Kingdom
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Oliver Stirrup,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliation UCL Institute for Global Health, London, United Kingdom
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Borscha Azmi,
Roles Investigation, Writing – review & editing
Affiliation UCL Institute of Health Informatics, London, United Kingdom
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Andrew Hayward,
Roles Conceptualization, Validation, Writing – review & editing
Affiliation United Kingdom Health Security Agency, London, United Kingdom
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Andrew Copas,
Roles Conceptualization, Investigation, Writing – review & editing
Affiliation UCL Institute for Global Health, London, United Kingdom
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Laura Shallcross ,
Contributed equally to this work with: Gokhan Tut, Tara Lancaster, Laura Shallcross, Paul Moss
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing
Affiliation UCL Institute of Health Informatics, London, United Kingdom
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Paul Moss ,
Contributed equally to this work with: Gokhan Tut, Tara Lancaster, Laura Shallcross, Paul Moss
Roles Conceptualization, Writing – original draft
* E-mail: p.moss@bham.ac.uk
Affiliation Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
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Crick COVID Immunity Pipeline
¶Membership of this group is shown in the acknowledgements.
Affiliation The Francis Crick Institute London, London, United Kingdom
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High rates of SARS-CoV-2 reinfection in residents of long term care facilities despite robust spike-specific immunity following serial vaccination
- Gokhan Tut,
- Tara Lancaster,
- Panagiota Sylla,
- David Bone,
- Christopher Bentley,
- Azar Jadir,
- Rachel Bruton,
- Katie Spencer,
- Soumyajit Mallick,
- Ahmed Elzaidi
- Published: August 14, 2026
- https://doi.org/10.1371/journal.pone.0354079